Photodynamic therapy for thin endometrium in patients with infertility

There is now evidence of certain structural and functional changes in the endometrium that may be etiological factors affecting reproductive system health. Endometrial hypoplasia alter-ations uterine hemodynamics cause implantation failure. Because thin associated with infertility, early miscarriage difficulty treating, further search use new therapeutic methods designed on basis domestic state-of-the-art technologies relevant. Effectiveness intracavitary photodynamic therapy (PDT) for patients was investigated. Fifty at age 35.4+/-3.3 years established diagnoses infertility were included study. All given PDT. Before treatment photosensitiser “Photoditazine” injected II phase menstrual cycle. For irradiation cavity medical apparatus “LAMI” providing laser radiation wavelength 660 nm, used. To distribute evenly light cavity, intrauterine cylinder optical fiber diffuser (OFD «KOVB-660») The average power density 0.05+/-0.02 W/cm2, energy 36.7+/-5.9 J/cm2, exposure time 11.7+/-2.25 min. We found PDT allows to correct cycle, achieve long-lasting clinical effect, regenerate thickness 3-layer structure endometrium, increase percentage recognised pregnancies reduce risk pregnancy complications.